Doode Flies does not remember anything about his life before becoming an adult. He has vague memories and terrible nightmares of a house with no doors or windows, trash covering every inch of the floor and flies...so many flies. Doode has assumed he was the unwilling subject of some deranged scientist but has found nothing to lend credence to this other than his loss of memory. He considers his real life to have begun the day he met his beautiful neighbor and future wife, Selene Strega.

Selene was out picking herbs for a house blessing spell she planned to cast on her new home when she came upon Doode standing outside of his house, staring at it as if seeing it for the first time. Intrigued by the strange and seemingly lost man, she struck up a conversation with him and an immediate friendship bloomed. A few months later she had moved in and a year after that, the happy couple were married.

Doode and Selene got into the field of Science to try and better figure out what happened to Doode before. So far, all experiments have failed to give a valid explanation for any of it.

Two months into their wedded life, Selene realized she was pregnant. Reyna was such a joy and light in their lives, the young couple knew they wanted more kids. Soon following were Karine and Elise.

After their three girls went on to college, Doode and Selene realized how much they missed the sounds of laughter and merriment in their home and went at creating a larger family with zest! Born to the attractive couple were then Adria, Falana, and Taryn.

During all of this family-making, Selene and Doode were also still intent on exploring the world of science and beyond - wild and daring experiments landed them both with children of their own. Doode was abducted by aliens and gave birth to a son, Corbin and Selene was able to seduce the Grim Reaper, producing a beautiful daughter, Samara. Both Doode and Selene love and raise Corbin and Samara as their own.

The large family eventually moved from Magda-Crist County to Strangetown where their unique family would be more accepted.